For Healthy Joints
Joint cartilage is not directly connected to any blood
vessels so all the nutrients that the cartilage needs
for good health have to be small enough to pass
through cellular walls to benefit the joint tissue.
The Cortaflex ® difference
Cortaflex ® was formulated around the theory that
smaller molecules are more likely to be absorbed
through cellular walls than larger ones and, therefore,
contains the micro sized key active isolates of
Chondroitin and Glucosamine. Cortaflex ® should
not be confused or compared with the many joint
supplements that rely on the larger sized Chondroitin
and Glucosamine molecules. These supplements
generally state that it may take several weeks before
there is any improvement in joint mobility.
By contrast, The Horse Journal reported that horses
on Cortaflex ® showed dramatic results in as little as
“After oral dosing, the mean bioavailability was 2.5%.
Determination of bioavailability after dosing to horses
provides evidence that glucosamine is absorbed orally,
Jianping Du et al. The bioavailability and
Pharmacokinetics of Glucosamine Hydrochloride and
Chondroitin Sulphate after Oral and Intravenous Single
Dose Administration in the Horse.
“The bioavailablity of the higher molecular weight
Chondroitin Sulphate was between 22% and 32%.”
Natalie D. Eddington et al. Taken from the Oral
Absorption of Chondroitin Sulphate as determined by
Total Disaccharide Content After Oral and Intravenous
Administration to Horses.
Avocado Soya Bean Unsaponifiable (ASU) is a wholly
natural substance that in recent clinical trials has
been shown to support horse’s joints, particularly in
older horses and those experiencing heavy work load.
Clinical evidence separates the
innovator from the imitator…
Cortaflex ® is the only equine joint supplement to
have been clinically tested in a double blind study
of equine tarsal joint movement pictured below.
The rigorous trial was conducted by the College of
Veterinary Medicine at Michigan State University,
one of the leading Equine research institutes in
the world. Unlike the more subjective research
approaches in the majority of equine trials, the
study used the most advanced kinetic analysis
techniques to objectively and accurately measure the
improvement in the horse’s gait. These techniques,
based on video and force plates, unquestionably
proved the improvement in gait asymmetry.
The results were then presented
by the author Dr. Hilary
Clayton BVMS, PhD,
MRVCS, to the A.A.E.P
of Equine Practitioners)
and published in the
Since the trial, Hyaluronic
Acid and ASU have been
added to the formulation,
reflecting the most recent
scientific findings of the
benefits of these two
substances in aiding
ICA Y •
LL The Cortaflex ® Hypothesis
is small molecules are more
likely to pass through cell
walls and into the joints.
Hyaluronic Acid is a major component of synovial
fluid which is essential for providing the joints with
lubrication and the cartilage with nutrients. The
Hyaluronic Acid used in Cortaflex is of vegetable
origin and has a low molecular weight of less than
fifty thousand Daltons which is believed makes it
readily absorbed, providing Hyaluronic Acid to the
joints in a non-invasive way.
ESTE KM ELITE PRODUCTS 33
Facts about joint cartilage
Cortaflex ® is fortified with Hyaluronic Acid (HA) and
ASU for even greater benefit to the joints, particularly
those that have experienced excessive wear and tear.
D Chondroitin, Glucosamine or Cortaflex ®
Hyaluronic Acid and ASU
Constant pounding on artificial, hard or heavy
ground is very demanding on joints - even hacking
can cause abnormal wear and tear. Feeding a
proven joint supplement can help to redress the
balance and support healthy joint function.
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