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For Healthy Joints Joint cartilage is not directly connected to any blood vessels so all the nutrients that the cartilage needs for good health have to be small enough to pass through cellular walls to benefit the joint tissue. The Cortaflex ® difference Cortaflex ® was formulated around the theory that smaller molecules are more likely to be absorbed through cellular walls than larger ones and, therefore, contains the micro sized key active isolates of Chondroitin and Glucosamine. Cortaflex ® should not be confused or compared with the many joint supplements that rely on the larger sized Chondroitin and Glucosamine molecules. These supplements generally state that it may take several weeks before there is any improvement in joint mobility. By contrast, The Horse Journal reported that horses on Cortaflex ® showed dramatic results in as little as three days! “After oral dosing, the mean bioavailability was 2.5%. Determination of bioavailability after dosing to horses provides evidence that glucosamine is absorbed orally, albeit low.” Jianping Du et al. The bioavailability and Pharmacokinetics of Glucosamine Hydrochloride and Chondroitin Sulphate after Oral and Intravenous Single Dose Administration in the Horse. “The bioavailablity of the higher molecular weight Chondroitin Sulphate was between 22% and 32%.” Natalie D. Eddington et al. Taken from the Oral Absorption of Chondroitin Sulphate as determined by Total Disaccharide Content After Oral and Intravenous Administration to Horses. Avocado Soya Bean Unsaponifiable (ASU) is a wholly natural substance that in recent clinical trials has been shown to support horse’s joints, particularly in older horses and those experiencing heavy work load. Clinical evidence separates the innovator from the imitator… Cortaflex ® is the only equine joint supplement to have been clinically tested in a double blind study of equine tarsal joint movement pictured below. The rigorous trial was conducted by the College of Veterinary Medicine at Michigan State University, one of the leading Equine research institutes in the world. Unlike the more subjective research approaches in the majority of equine trials, the study used the most advanced kinetic analysis techniques to objectively and accurately measure the improvement in the horse’s gait. These techniques, based on video and force plates, unquestionably proved the improvement in gait asymmetry. The results were then presented by the author Dr. Hilary Clayton BVMS, PhD, MRVCS, to the A.A.E.P (American Association of Equine Practitioners) and published in the conference proceedings. Since the trial, Hyaluronic Acid and ASU have been added to the formulation, reflecting the most recent scientific findings of the benefits of these two substances in aiding joint mobility. T IN ICA Y • LL The Cortaflex ® Hypothesis is small molecules are more likely to pass through cell walls and into the joints. Hyaluronic Acid is a major component of synovial fluid which is essential for providing the joints with lubrication and the cartilage with nutrients. The Hyaluronic Acid used in Cortaflex is of vegetable origin and has a low molecular weight of less than fifty thousand Daltons which is believed makes it readily absorbed, providing Hyaluronic Acid to the joints in a non-invasive way. ESTE KM ELITE PRODUCTS 33 Facts about joint cartilage Cortaflex ® is fortified with Hyaluronic Acid (HA) and ASU for even greater benefit to the joints, particularly those that have experienced excessive wear and tear. D Chondroitin, Glucosamine or Cortaflex ® Hyaluronic Acid and ASU • CL Constant pounding on artificial, hard or heavy ground is very demanding on joints - even hacking can cause abnormal wear and tear. Feeding a proven joint supplement can help to redress the balance and support healthy joint function. CORTAFLEX ® CONTACT US: 01403 759659 | WWW.KMELITEPRODUCTS.CO.UK | FOLLOW US: